Animal rights activists are targeting government ministers and farm leaders over plans for a badger cull to combat bovine tuberculosis.
The Nottingham-based group has invited hundreds of supporters to attend the protest, which is timed for the morning of Tuesday, 21 February.
DEFRA secretary Caroline Spelman is due to make a keynote speech to delegates at the ICC conference centre at 10.45am the same day.
A Facebook page to publicise the protest shows that Animal Rights UK has sent invitations to 1,804 supporters.
It is believed that the Facebook page was set up on Thursday (12 January).
By noon on Friday (13 January), some 34 supporters said they would be attending the protest. More are expected to follow although some have cited work commitments for not attending.
The protest webpage describes the NFU as the “No. 1 driving force” behind government plans for a pilot cull later this year to combat bovine TB in cattle.
“This is a collection of individuals and corporations most responsible for pushing the proposed badger cull through parliament,” it says.
Highlighting Mrs Spelman’s past employment as an NFU sugar beet secretary, the webpage says the union has strong political ties.
“During their fringe event at the Conservative Party conference, they were boasting how they will be getting the badger cull approved.”
It adds: “We urge as many animal lovers to join us outside the ICC for a huge protest to show Caroline Spelman and the NFU that we will not allow the badger cull.”
The NFU believes a carefully managed and licensed badger cull is vital to reduce the prevalence of bovine tuberculosis in cattle.
Pilot culls scheduled for this autumn aim to test whether the controlled shooting of badgers is humane, effective and safe.
Badgers are considered to be one of the main vectors for bovine TB, which costs the taxpayer up to £100m a year.
DEFRA has warned the disease will cost £1bn in England alone over the next decade unless more action is taken.
Farm minister Jim Paice held talks with police chiefs before Christmas about the best way of dealing with anti-cull protestors.
He told Farmers Weekly: “Those involved in licensed activities will be acting within the law and are entitled to carry out those activities without intimidation.”